Nptn | neuroplastin

GeneMGI:108077Synonyms: Sdfr1, NP65

Physiological systems

20 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hearing/vestibular/ear Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

10 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	2 supporting datasets	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.61x10^-29
abnormal auditory brainstem response	5 supporting datasets	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.15x10^-7
decreased anxiety-related response	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.98x10^-11
decreased prepulse inhibition	6 supporting datasets	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.87x10^-22
abnormal iris morphology	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.63x10^-5
increased hemoglobin content	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.54x10^-7
decreased thigmotaxis	2 supporting datasets	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.98x10^-18
abnormal ear morphology	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.91x10^-24
decreased total body fat amount	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.6x10^-5
limb grasping	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.35x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Nptn.

Associated images

Loading...

Histopathology

There is no histopathology data found for Nptn.

IMPC related publications

Loading...

External links

No external links available for Nptn.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Nptn^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nptn^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nptn^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes