Nptn | neuroplastin

GeneMGI:108077Synonyms: Sdfr1, NP65

Physiological systems

20 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hearing/vestibular/ear Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

10 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	2 supporting datasets	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.61x10^-29
abnormal auditory brainstem response	5 supporting datasets	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.15x10^-7
decreased anxiety-related response	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.98x10^-11
decreased prepulse inhibition	6 supporting datasets	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.87x10^-22
abnormal iris morphology	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.63x10^-5
increased hemoglobin content	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.54x10^-7
decreased thigmotaxis	2 supporting datasets	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.98x10^-18
abnormal ear morphology	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.91x10^-24
decreased total body fat amount	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.6x10^-5
limb grasping	1 supporting dataset	Nptn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.35x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nptn.

Associated images

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Histopathology

There is no histopathology data found for Nptn.

IMPC related publications

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External links

No external links available for Nptn.

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*Nptn^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Nptn^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nptn^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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