Stx2 | syntaxin 2

GeneMGI:108059Synonyms: Syn-2, Epim, +2 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Vision/eye Hematopoietic system

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



increased circulating cholesterol level	1 supporting dataset	Stx2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.79x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Stx2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.11x10^-5
decreased mean corpuscular volume	1 supporting dataset	Stx2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.17x10^-28
increased erythrocyte cell number	1 supporting dataset	Stx2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.15x10^-7
decreased mean corpuscular hemoglobin	1 supporting dataset	Stx2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.33x10^-51
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Stx2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.12x10^-6
cataract	1 supporting dataset	Stx2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.73x10^-6
male infertility	1 supporting dataset	Stx2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Stx2.

Associated images

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Histopathology

There is no histopathology data found for Stx2.

IMPC related publications

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External links

No external links available for Stx2.

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*Stx2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Stx2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Stx2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Stx2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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