Atr | ataxia telangiectasia and Rad3 related
GeneMGI:108028
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Nervous system Mortality/aging Cardiovascular system
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
4Associated diseases
Expression examined in:49Adult tissues
21Embryo tissues
| increased fasting circulating glucose level | 1 supporting dataset | Atrtm1b(KOMP)Wtsi | heterozygote | Early adult | 1.5x10-5 | ||
| abnormal spinal cord morphology | 1 supporting dataset | Atrtm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Atrtm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| decreased circulating glucose level | 2 supporting datasets | Atrtm1b(KOMP)Wtsi | heterozygote | Early adult | 4.67x10-6 | ||
| increased heart weight | 1 supporting dataset | Atrtm1b(KOMP)Wtsi | heterozygote | Early adult | 3.1x10-7 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Atrtm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Atrtm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
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External links
No external links available for Atr.
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| Atrtm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Atrtm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |