Pkn1 | protein kinase N1

GeneMGI:108022Synonyms: Stk3, PRK1, +4 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Hematopoietic system

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased lymphocyte cell number	1 supporting dataset	Pkn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.22x10^-11
decreased neutrophil cell number	2 supporting datasets	Pkn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.21x10^-13
decreased large unstained cell number	1 supporting dataset	Pkn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.52x10^-7
increased total body fat amount	2 supporting datasets	Pkn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.01x10^-9
decreased monocyte cell number	1 supporting dataset	Pkn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.15x10^-5
decreased leukocyte cell number	1 supporting dataset	Pkn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.8x10^-12
decreased fasting circulating glucose level	1 supporting dataset	Pkn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.29x10^-5
decreased red blood cell distribution width	1 supporting dataset	Pkn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.14x10^-5
increased hemoglobin content	1 supporting dataset	Pkn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.19x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pkn1.

Associated images

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Histopathology

There is no histopathology data found for Pkn1.

IMPC related publications

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External links

No external links available for Pkn1.

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*Pkn1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pkn1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pkn1^{tm44436(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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