D6Wsu163e | DNA segment, Chr 6, Wayne State University 163, expressed

GeneMGI:107893

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating fructosamine level	1 supporting dataset	D6Wsu163e^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.12x10^-6
increased circulating total protein level	1 supporting dataset	D6Wsu163e^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.94x10^-8
increased circulating cholesterol level	1 supporting dataset	D6Wsu163e^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9x10^-6
increased CD8-positive, alpha-beta T cell number	3 supporting datasets	D6Wsu163e^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased memory-marker NK cell number	2 supporting datasets	D6Wsu163e^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased CD4-positive, alpha-beta T cell number	2 supporting datasets	D6Wsu163e^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal auditory brainstem response	1 supporting dataset	D6Wsu163e^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.54x10^-9
increased CD8-positive, naive alpha-beta T cell number	1 supporting dataset	D6Wsu163e^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	D6Wsu163e^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.93x10^-75
decreased circulating glucose level	1 supporting dataset	D6Wsu163e^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.25x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for D6Wsu163e.

Associated images

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Histopathology

There is no histopathology data found for D6Wsu163e.

IMPC related publications

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External links

No external links available for D6Wsu163e.

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*D6Wsu163e^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*D6Wsu163e^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*D6Wsu163e^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*D6Wsu163e^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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