Casp4 | caspase 4, apoptosis-related cysteine peptidase

GeneMGI:107700Synonyms: Caspase-11, ich-3, +1 more

Physiological systems

21 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Respiratory system

19 No significant impact

3 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

decreased pulmonary ventilation1 supporting datasetCasp4tm1b(KOMP)WtsihomozygoteEarly adult1.04x10-5 
increased circulating glucose level1 supporting datasetCasp4tm1b(KOMP)WtsihomozygoteEarly adult1.23x10-6 
increased circulating calcium level1 supporting datasetCasp4tm1b(KOMP)WtsihomozygoteEarly adult4.08x10-5 
increased circulating bilirubin level1 supporting datasetCasp4tm1b(KOMP)WtsihomozygoteEarly adult2.21x10-6 
increased circulating insulin level1 supporting datasetCasp4tm1b(KOMP)WtsihomozygoteEarly adult9.31x10-10 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Casp4tm1(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell
Casp4tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Casp4tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Casp4tm2(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell

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