Irgm1 | immunity-related GTPase family M member 1

GeneMGI:107567Synonyms: Irgm, Ifi1, +2 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating serum albumin level	1 supporting dataset	Irgm1^{em1(IMPC)Wtsi}	homozygote	Early adult	1.23x10^-8
increased lean body mass	1 supporting dataset	Irgm1^{em1(IMPC)Wtsi}	homozygote	Early adult	6.49x10^-7
increased circulating LDL cholesterol level	1 supporting dataset	Irgm1^{em1(IMPC)Wtsi}	homozygote	Early adult	1.15x10^-5
decreased hematocrit	1 supporting dataset	Irgm1^{em1(IMPC)Wtsi}	homozygote	Early adult	3.53x10^-14
increased mean platelet volume	1 supporting dataset	Irgm1^{em1(IMPC)Wtsi}	homozygote	Early adult	6.79x10^-42
decreased hemoglobin content	1 supporting dataset	Irgm1^{em1(IMPC)Wtsi}	homozygote	Early adult	1.94x10^-19
increased red blood cell distribution width	1 supporting dataset	Irgm1^{em1(IMPC)Wtsi}	homozygote	Early adult	5.96x10^-33
decreased fasting circulating glucose level	1 supporting dataset	Irgm1^{em1(IMPC)Wtsi}	homozygote	Early adult	6.05x10^-10
increased circulating aspartate transaminase level	1 supporting dataset	Irgm1^{em1(IMPC)Wtsi}	homozygote	Early adult	3.83x10^-6
decreased circulating fructosamine level	1 supporting dataset	Irgm1^{em1(IMPC)Wtsi}	homozygote	Early adult	2.46x10^-13

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Irgm1.

Associated images

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Histopathology

There is no histopathology data found for Irgm1.

IMPC related publications

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External links

No external links available for Irgm1.

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*Irgm1^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Irgm1^{tm470641(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes