Lyst | lysosomal trafficking regulator

GeneMGI:107448Synonyms: D13Sfk13

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Pigmentation Integument Nervous system Vision/eye Hematopoietic system Behavior/neurological Mortality/aging

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased grip strength	1 supporting dataset	Lyst^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.1x10^-6
abnormal coat/hair pigmentation	3 supporting datasets	Lyst^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.14x10^-25
abnormal retina morphology	1 supporting dataset	Lyst^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.91x10^-14
increased mean corpuscular hemoglobin	1 supporting dataset	Lyst^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.03x10^-6
increased mean corpuscular volume	1 supporting dataset	Lyst^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.63x10^-5
decreased locomotor activity	1 supporting dataset	Lyst^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.63x10^-7
preweaning lethality, incomplete penetrance	1 supporting dataset	Lyst^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased prepulse inhibition	1 supporting dataset	Lyst^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.89x10^-5
abnormal iris morphology	1 supporting dataset	Lyst^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.25x10^-17

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lyst.

Associated images

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Histopathology

There is no histopathology data found for Lyst.

IMPC related publications

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External links

No external links available for Lyst.

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*Lyst^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Lyst^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lyst^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Lyst^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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