Cct5 | chaperonin containing TCP1 subunit 5

GeneMGI:107185Synonyms: TCPE, Ccte

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Reproductive system Integument Embryo Growth/size/body region Limbs/digits/tail Vision/eye Mortality/aging

13 No significant impact

4 Not tested

Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsCct5em1(IMPC)TcphomozygoteEarly adultN/A * 
abnormal embryo size1 supporting datasetCct5em1(IMPC)TcpheterozygoteE9.5N/A * 
abnormal uterus morphology1 supporting datasetCct5em1(IMPC)TcpheterozygoteEarly adultN/A * 
embryonic growth retardation1 supporting datasetCct5em1(IMPC)TcpheterozygoteE9.5N/A * 
embryonic lethality prior to organogenesis1 supporting datasetCct5em1(IMPC)TcphomozygoteE9.5N/A * 
abnormal skin morphology1 supporting datasetCct5em1(IMPC)TcpheterozygoteEarly adultN/A * 
prenatal lethality prior to heart atrial septation1 supporting datasetCct5em1(IMPC)TcphomozygoteE15.5N/A * 
abnormal digit morphology1 supporting datasetCct5em1(IMPC)TcpheterozygoteEarly adult4.43x10-5 
abnormal retina morphology1 supporting datasetCct5em1(IMPC)TcpheterozygoteEarly adult7.69x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cct5em1(IMPC)TcpExon Deletionmouse
Cct5tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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