Aff3 | AF4/FMR2 family, member 3

GeneMGI:106927Synonyms: Laf4, LAF-4, +1 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Behavior/neurological Skeleton Craniofacial

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



fusion of vertebral arches	1 supporting dataset	Aff3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.64x10^-6
abnormal incisor morphology	1 supporting dataset	Aff3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.74x10^-7
abnormal snout morphology	1 supporting dataset	Aff3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.93x10^-5
increased circulating chloride level	1 supporting dataset	Aff3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.7x10^-5
abnormal vertebral arch morphology	1 supporting dataset	Aff3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.07x10^-7
decreased grip strength	1 supporting dataset	Aff3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.01x10^-5
vertebral transformation	1 supporting dataset	Aff3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.79x10^-6
abnormal tooth morphology	1 supporting dataset	Aff3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.26x10^-6
decreased circulating serum albumin level	1 supporting dataset	Aff3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.15x10^-6
decreased circulating fructosamine level	1 supporting dataset	Aff3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.74x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aff3.

Associated images

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Histopathology

There is no histopathology data found for Aff3.

IMPC related publications

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External links

No external links available for Aff3.

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*Aff3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Aff3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Aff3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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