Abi2 | abl interactor 2

GeneMGI:106913Synonyms: 8430425M24Rik

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Pigmentation Endocrine/exocrine gland Nervous system Vision/eye Behavior/neurological Renal/urinary system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal iris morphology	1 supporting dataset	Abi2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.09x10^-15
abnormal cornea morphology	1 supporting dataset	Abi2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.35x10^-16
decreased locomotor activity	2 supporting datasets	Abi2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.18x10^-6
abnormal iris pigmentation	1 supporting dataset	Abi2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.08x10^-18
increased fasting circulating glucose level	1 supporting dataset	Abi2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.04x10^-5
absent urinary bladder	1 supporting dataset	Abi2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased prepulse inhibition	3 supporting datasets	Abi2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.58x10^-6
small testis	1 supporting dataset	Abi2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Abi2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Abi2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.98x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Abi2.

Associated images

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Histopathology

There is no histopathology data found for Abi2.

IMPC related publications

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External links

No external links available for Abi2.

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*Abi2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Abi2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Abi2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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