Dusp8 | dual specificity phosphatase 8

GeneMGI:106626Synonyms: Nttp1, 5530400B01Rik

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Growth/size/body region Nervous system Vision/eye Behavior/neurological Cardiovascular system Renal/urinary system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



small kidney	2 supporting datasets	Dusp8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased brain weight	1 supporting dataset	Dusp8^em1(IMPC)Mbp	homozygote	Early adult	6.61x10^-20
abnormal kidney morphology	2 supporting datasets	Dusp8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal brain morphology	2 supporting datasets	Dusp8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Dusp8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased brain size	2 supporting datasets	Dusp8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
impaired glucose tolerance	1 supporting dataset	Dusp8^em1(IMPC)Mbp	homozygote	Early adult	3.41x10^-13
decreased grip strength	1 supporting dataset	Dusp8^em1(IMPC)Mbp	homozygote	Early adult	2.69x10^-7
abnormal retina vasculature morphology	1 supporting dataset	Dusp8^em1(IMPC)Mbp	homozygote	Early adult	7.74x10^-5
decreased body length	1 supporting dataset	Dusp8^em1(IMPC)Mbp	homozygote	Early adult	2.62x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dusp8.

Associated images

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Histopathology

There is no histopathology data found for Dusp8.

IMPC related publications

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External links

No external links available for Dusp8.

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*Dusp8^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Dusp8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dusp8^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dusp8^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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