Mbd6 | methyl-CpG binding domain protein 6

GeneMGI:106378Synonyms: D10Wsu93e

Physiological systems

23 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Digestive/alimentary Nervous system Cardiovascular system Mortality/aging Craniofacial Renal/urinary system

14 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

84Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



cleft palate	1 supporting dataset	Mbd6^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
increased kidney weight	2 supporting datasets	Mbd6^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.6x10^-7
spina bifida	1 supporting dataset	Mbd6^{tm1.1(KOMP)Vlcg}	heterozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Mbd6^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Mbd6^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Mbd6^{tm1.1(KOMP)Vlcg}	heterozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Mbd6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Mbd6^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	5.54x10^-9
spina bifida	1 supporting dataset	Mbd6^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
edema	1 supporting dataset	Mbd6^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mbd6.

Associated images

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Histopathology

There is no histopathology data found for Mbd6.

IMPC related publications

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External links

No external links available for Mbd6.

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*Mbd6^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Mbd6^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Mbd6^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Mbd6^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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