Capza1 | capping actin protein of muscle Z-line subunit alpha 1

GeneMGI:106227Synonyms: Cappa1

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Integument Limbs/digits/tail Vision/eye Hematopoietic system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



thrombocytopenia	1 supporting dataset	Capza1^em1(IMPC)Tcp	homozygote	Early adult	7.33x10^-9
cataract	1 supporting dataset	Capza1^em1(IMPC)Tcp	homozygote	Early adult	5.39x10^-6
decreased leukocyte cell number	1 supporting dataset	Capza1^em1(IMPC)Tcp	homozygote	Early adult	8.18x10^-6
increased mean platelet volume	1 supporting dataset	Capza1^em1(IMPC)Tcp	homozygote	Early adult	1.03x10^-30
decreased lymphocyte cell number	1 supporting dataset	Capza1^em1(IMPC)Tcp	homozygote	Early adult	1.65x10^-5
decreased hematocrit	1 supporting dataset	Capza1^em1(IMPC)Tcp	homozygote	Early adult	3.67x10^-5
increased monocyte cell number	1 supporting dataset	Capza1^em1(IMPC)Tcp	homozygote	Early adult	1.59x10^-5
abnormal skin morphology	2 supporting datasets	Capza1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased mean corpuscular volume	1 supporting dataset	Capza1^em1(IMPC)Tcp	homozygote	Early adult	7.74x10^-8
abnormal tail morphology	1 supporting dataset	Capza1^em1(IMPC)Tcp	homozygote	Early adult	1.28x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Capza1.

Associated images

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Histopathology

There is no histopathology data found for Capza1.

IMPC related publications

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External links

No external links available for Capza1.

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*Capza1^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Capza1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Capza1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Capza1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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