Loxl1 | lysyl oxidase-like 1

GeneMGI:106096Synonyms: LOXL

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Nervous system Vision/eye Behavior/neurological

13 No significant impact

7 Not tested

Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:52Adult tissues
47Embryo tissues

Phenotypes

decreased circulating total protein level1 supporting datasetLoxl1tm1.1(KOMP)VlcghomozygoteEarly adult1.75x10-5 
increased fasting circulating glucose level1 supporting datasetLoxl1tm1.1(KOMP)VlcgheterozygoteEarly adult3.95x10-5 
abnormal retina morphology1 supporting datasetLoxl1tm1.1(KOMP)VlcghomozygoteEarly adult6.17x10-5 
abnormal sleep behavior2 supporting datasetsLoxl1tm1.1(KOMP)VlcghomozygoteEarly adult1.52x10-8 
convulsive seizures1 supporting datasetLoxl1tm1.1(KOMP)VlcghomozygoteEarly adult7.1x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Loxl1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Loxl1tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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