Rab5a | RAB5A, member RAS oncogene family

GeneMGI:105926Synonyms: 2410015H04Rik

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Phy. System:



increased circulating sodium level	1 supporting dataset	Rab5a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.24x10^-5
increased heart weight	1 supporting dataset	Rab5a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.55x10^-5
increased circulating potassium level	1 supporting dataset	Rab5a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.18x10^-6
decreased grip strength	1 supporting dataset	Rab5a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.12x10^-5
decreased mean corpuscular hemoglobin	1 supporting dataset	Rab5a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.23x10^-5
increased erythrocyte cell number	1 supporting dataset	Rab5a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.69x10^-6
abnormal sleep behavior	1 supporting dataset	Rab5a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.1x10^-7
decreased mean corpuscular volume	1 supporting dataset	Rab5a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.16x10^-5
increased startle reflex	1 supporting dataset	Rab5a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.61x10^-11
abnormal retina morphology	1 supporting dataset	Rab5a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.79x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Rab5a.

Associated images

Loading...

Histopathology

There is no histopathology data found for Rab5a.

IMPC related publications

Loading...

External links

No external links available for Rab5a.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Rab5a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rab5a^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

My Genes