Cxcr2 | C-X-C motif chemokine receptor 2

GeneMGI:105303Synonyms: IL-8rb, IL8RA, +5 more

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:37Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased CD8-positive, alpha-beta memory T cell number	3 supporting datasets	Cxcr2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased memory-marker NK cell number	1 supporting dataset	Cxcr2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
improved glucose tolerance	1 supporting dataset	Cxcr2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.8x10^-6
decreased B cell number	2 supporting datasets	Cxcr2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased pre-B cell number	1 supporting dataset	Cxcr2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased gamma-delta T cell number	4 supporting datasets	Cxcr2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased anti-nuclear antigen antibody level	4 supporting datasets	Cxcr2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased monocyte cell number	4 supporting datasets	Cxcr2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Cxcr2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.07x10^-5
decreased CD8-positive, alpha-beta T cell number	2 supporting datasets	Cxcr2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cxcr2.

Associated images

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Histopathology

There is no histopathology data found for Cxcr2.

IMPC related publications

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External links

No external links available for Cxcr2.

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*Cxcr2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cxcr2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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