Ube3a | ubiquitin protein ligase E3A

GeneMGI:105098Synonyms: 5830462N02Rik, A130086L21Rik, +2 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Adipose tissue Hematopoietic system Behavior/neurological Skeleton

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased bone mineral density	1 supporting dataset	Ube3a^{em1(IMPC)Hmgu}	homozygote	Early adult	3.13x10^-5
decreased vertical activity	1 supporting dataset	Ube3a^{em1(IMPC)Hmgu}	homozygote	Early adult	7.28x10^-13
decreased locomotor activity	7 supporting datasets	Ube3a^{em1(IMPC)Hmgu}	homozygote	Early adult	5.7x10^-11
hyperactivity	3 supporting datasets	Ube3a^{em1(IMPC)Hmgu}	homozygote	Early adult	8.12x10^-7
decreased food intake	1 supporting dataset	Ube3a^{em1(IMPC)Hmgu}	homozygote	Early adult	6.4x10^-6
decreased locomotor activity	4 supporting datasets	Ube3a^{em1(IMPC)Hmgu}	heterozygote	Early adult	1.38x10^-6
decreased respiratory quotient	1 supporting dataset	Ube3a^{em1(IMPC)Hmgu}	heterozygote	Early adult	5.85x10^-7
decreased respiratory quotient	1 supporting dataset	Ube3a^{em1(IMPC)Hmgu}	homozygote	Early adult	2x10^-6
decreased bone mineral content	1 supporting dataset	Ube3a^{em1(IMPC)Hmgu}	homozygote	Early adult	9.14x10^-8
increased total body fat amount	1 supporting dataset	Ube3a^{em1(IMPC)Hmgu}	homozygote	Early adult	4.39x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ube3a.

Associated images

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Histopathology

There is no histopathology data found for Ube3a.

IMPC related publications

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External links

No external links available for Ube3a.

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*Ube3a^{em1(IMPC)Hmgu}*	Deletion	‌	mouse
*Ube3a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ube3a^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ube3a^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ube3a^{tm3e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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