Rbl2 | RB transcriptional corepressor like 2

GeneMGI:105085Synonyms: p130, Rb2, +1 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

1Associated diseases

Expression examined in:49Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Rbl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Rbl2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.39x10^-6
abnormal retina morphology	1 supporting dataset	Rbl2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.79x10^-5
persistence of hyaloid vascular system	1 supporting dataset	Rbl2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.24x10^-5
increased circulating cholesterol level	1 supporting dataset	Rbl2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.24x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rbl2.

Associated images

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Histopathology

There is no histopathology data found for Rbl2.

IMPC related publications

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External links

No external links available for Rbl2.

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*Rbl2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rbl2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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