Gpc4 | glypican 4

GeneMGI:104902Synonyms: 9530073D23Rik, K-glypican

Physiological systems

16 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Craniofacial

10 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

3Associated diseases

Expression examined in:96Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating bilirubin level	1 supporting dataset	Gpc4^{tm2b(EUCOMM)Wtsi}	hemizygote	Early adult	1.94x10^-8
decreased grip strength	1 supporting dataset	Gpc4^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	3.51x10^-5
increased circulating bilirubin level	1 supporting dataset	Gpc4^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.87x10^-7
increased mean corpuscular hemoglobin	1 supporting dataset	Gpc4^{tm2b(EUCOMM)Wtsi}	hemizygote	Early adult	4.58x10^-7
decreased fasting circulating glucose level	1 supporting dataset	Gpc4^{tm2b(EUCOMM)Wtsi}	hemizygote	Early adult	1.16x10^-13
abnormal snout morphology	1 supporting dataset	Gpc4^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.97x10^-7
decreased circulating creatinine level	1 supporting dataset	Gpc4^{tm2b(EUCOMM)Wtsi}	hemizygote	Early adult	4.62x10^-5
abnormal cholesterol homeostasis	1 supporting dataset	Gpc4^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.16x10^-6
decreased blood urea nitrogen level	1 supporting dataset	Gpc4^{tm2b(EUCOMM)Wtsi}	hemizygote	Early adult	6.6x10^-5
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Gpc4^{tm2b(EUCOMM)Wtsi}	hemizygote	Early adult	1.1x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gpc4.

Associated images

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Histopathology

There is no histopathology data found for Gpc4.

IMPC related publications

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External links

No external links available for Gpc4.

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*Gpc4^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Gpc4^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Gpc4^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gpc4^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gpc4^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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