Rest | RE1-silencing transcription factor

GeneMGI:104897Synonyms: NRSF, 2610008J04Rik

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Hearing/vestibular/ear Hematopoietic system Cardiovascular system Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

5Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased mean platelet volume	1 supporting dataset	Rest^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	8.51x10^-5
decreased heart rate	1 supporting dataset	Rest^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	8.19x10^-5
abnormal auditory brainstem response	1 supporting dataset	Rest^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	2.35x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Rest^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rest.

Associated images

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Histopathology

There is no histopathology data found for Rest.

IMPC related publications

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External links

No external links available for Rest.

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*Rest^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Rest^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Rest^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Rest^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rest^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rest^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Rest^{tm47385(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes