Lcp1 | lymphocyte cytosolic protein 1

GeneMGI:104808Synonyms: D14Ertd310e, L-plastin, +2 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Lcp1^{tm1e.1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Lcp1^{tm1e.1(KOMP)Wtsi}	heterozygote	Early adult	2.42x10^-12
thrombocytopenia	1 supporting dataset	Lcp1^{tm1e.1(KOMP)Wtsi}	heterozygote	Early adult	1.94x10^-5
decreased hematocrit	1 supporting dataset	Lcp1^{tm1e.1(KOMP)Wtsi}	heterozygote	Early adult	6.32x10^-13
increased fasting circulating glucose level	1 supporting dataset	Lcp1^{tm1e.1(KOMP)Wtsi}	heterozygote	Early adult	7.15x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lcp1.

Associated images

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Histopathology

There is no histopathology data found for Lcp1.

IMPC related publications

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External links

No external links available for Lcp1.

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*Lcp1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Lcp1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	mouse
*Lcp1^{tm1e.1(KOMP)Wtsi}*	Promoter excision from Targeted, non-conditional allele	‌	mouse
*Lcp1^{tm43058(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Lcp1^{tm43058(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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