Sik1 | salt inducible kinase 1

GeneMGI:104754Synonyms: Snf1lk, Msk

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Cardiovascular system Renal/urinary system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

4Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased bone mineral content	1 supporting dataset	Sik1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.12x10^-5
decreased total body fat amount	1 supporting dataset	Sik1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.67x10^-9
increased lean body mass	1 supporting dataset	Sik1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.4x10^-8
increased circulating alkaline phosphatase level	1 supporting dataset	Sik1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.03x10^-6
increased kidney weight	2 supporting datasets	Sik1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.37x10^-12
decreased circulating total protein level	1 supporting dataset	Sik1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.55x10^-5
increased heart weight	2 supporting datasets	Sik1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.6x10^-10
decreased circulating cholesterol level	1 supporting dataset	Sik1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.43x10^-6
decreased circulating serum albumin level	1 supporting dataset	Sik1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.25x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sik1.

Associated images

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Histopathology

There is no histopathology data found for Sik1.

IMPC related publications

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External links

No external links available for Sik1.

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*Sik1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Sik1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Sik1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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