Atn1 | atrophin 1

GeneMGI:104725Synonyms: Atr1, Drpla, +1 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

3Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



increased heart rate variability	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.86x10^-7
increased circulating triglyceride level	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.02x10^-5
abnormal gait	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.4x10^-12
decreased exploration in new environment	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.81x10^-6
increased mean corpuscular hemoglobin	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.14x10^-5
abnormal sinus arrhythmia	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.89x10^-5
decreased erythrocyte cell number	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.52x10^-5
abnormal skin morphology	2 supporting datasets	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
cataract	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.35x10^-5
limb grasping	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.45x10^-14

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Atn1.

Associated images

Loading...

Histopathology

There is no histopathology data found for Atn1.

IMPC related publications

Loading...

External links

No external links available for Atn1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Atn1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Atn1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Atn1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Atn1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes