Atn1 | atrophin 1

GeneMGI:104725Synonyms: Atr1, Drpla, +1 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

3Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



increased heart rate variability	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.86x10^-7
increased circulating triglyceride level	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.02x10^-5
abnormal gait	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.4x10^-12
decreased exploration in new environment	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.81x10^-6
increased mean corpuscular hemoglobin	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.14x10^-5
abnormal sinus arrhythmia	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.89x10^-5
decreased erythrocyte cell number	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.52x10^-5
abnormal skin morphology	2 supporting datasets	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
cataract	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.35x10^-5
limb grasping	1 supporting dataset	Atn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.45x10^-14

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atn1.

Associated images

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Histopathology

There is no histopathology data found for Atn1.

IMPC related publications

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External links

No external links available for Atn1.

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*Atn1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Atn1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Atn1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Atn1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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