Wbp2 | WW domain binding protein 2

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Immune system Hematopoietic system Behavior/neurological

17 No significant impact

4 Not tested

Data collections

Viability data
Body weight measurements
Embryo imaging data
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

increased startle reflex4 supporting datasetsWbp2tm2a(EUCOMM)WtsihomozygoteEarly adult2.97x10-8 
abnormal behavior3 supporting datasetsWbp2tm2a(EUCOMM)WtsihomozygoteEarly adult1.46x10-9 
decreased hematocrit1 supporting datasetWbp2tm2a(EUCOMM)WtsihomozygoteEarly adult2.51x10-7 
hyperactivity2 supporting datasetsWbp2tm2a(EUCOMM)WtsihomozygoteEarly adult4.85x10-10 
decreased erythrocyte cell number1 supporting datasetWbp2tm2a(EUCOMM)WtsihomozygoteEarly adult3.32x10-8 
increased leukocyte cell number1 supporting datasetWbp2tm2a(EUCOMM)WtsihomozygoteEarly adult3.9x10-5 
absent pinna reflex1 supporting datasetWbp2tm2a(EUCOMM)WtsihomozygoteEarly adult9.35x10-8 
decreased hemoglobin content1 supporting datasetWbp2tm2a(EUCOMM)WtsihomozygoteEarly adult5.33x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Wbp2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Wbp2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Wbp2tm1e(EUCOMM)WtsiTargeted, non-conditional allelees cell
Wbp2tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse

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