Ptpn12 | protein tyrosine phosphatase, non-receptor type 12
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Mortality/aging Cardiovascular system
14 No significant impact
5 Not tested
Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
29Embryo tissues
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Ptpn12tm1b(NCOM)Mfgc | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Ptpn12tm1b(NCOM)Mfgc | heterozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ptpn12tm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Ptpn12tm1b(NCOM)Mfgc | homozygote | E9.5 | N/A * | ||
| abnormal pericardium morphology | 1 supporting dataset | Ptpn12tm1b(NCOM)Mfgc | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Ptpn12tm1b(NCOM)Mfgc | homozygote | E9.5 | N/A * | ||
| edema | 1 supporting dataset | Ptpn12tm1b(NCOM)Mfgc | homozygote | E9.5 | N/A * |
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External links
No external links available for Ptpn12.
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| Ptpn12tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Ptpn12tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ptpn12tm1a(NCOM)Mfgc | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ptpn12tm1b(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ptpn12tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |