Tle3 | transducin-like enhancer of split 3

GeneMGI:104634Synonyms: 2610103N05Rik, ESG, +2 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Nervous system Vision/eye Hematopoietic system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	1 supporting dataset	Tle3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased brain size	2 supporting datasets	Tle3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal brain morphology	2 supporting datasets	Tle3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
cataract	1 supporting dataset	Tle3^em1(IMPC)Mbp	homozygote	Early adult	3.48x10^-8
abnormal testis morphology	1 supporting dataset	Tle3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Tle3^em1(IMPC)Mbp	homozygote	Early adult	3.31x10^-8
persistence of hyaloid vascular system	1 supporting dataset	Tle3^em1(IMPC)Mbp	homozygote	Early adult	4.33x10^-6
small testis	1 supporting dataset	Tle3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small spleen	1 supporting dataset	Tle3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tle3.

Associated images

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Histopathology

There is no histopathology data found for Tle3.

IMPC related publications

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External links

No external links available for Tle3.

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*Tle3^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Tle3^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell

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