Tle4 | transducin-like enhancer of split 4

GeneMGI:104633Synonyms: 5730411M05Rik, Bce1, +3 more

Physiological systems

21 / 24 physiological systems tested

15 Significantly impacted by the knock-out

Reproductive system Immune system Integument Adipose tissue Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Cardiovascular system Renal/urinary system Homeostasis/metabolism Nervous system Vision/eye Liver/biliary system Behavior/neurological Skeleton

6 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal skin morphology	1 supporting dataset	Tle4^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
decreased grip strength	1 supporting dataset	Tle4^em1(IMPC)Mbp	homozygote	Early adult	1.33x10^-6
decreased lean body mass	2 supporting datasets	Tle4^em1(IMPC)Mbp	homozygote	Early adult	1.72x10^-10
decreased heart weight	2 supporting datasets	Tle4^em1(IMPC)Mbp	homozygote	Early adult	3.15x10^-5
increased total body fat amount	2 supporting datasets	Tle4^em1(IMPC)Mbp	homozygote	Early adult	1.39x10^-10
small kidney	1 supporting dataset	Tle4^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Tle4^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Tle4^em1(IMPC)Mbp	homozygote	Early adult	3.52x10^-9
abnormal eye morphology	1 supporting dataset	Tle4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal rectum morphology	1 supporting dataset	Tle4^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tle4.

Associated images

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Histopathology

There is no histopathology data found for Tle4.

IMPC related publications

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External links

No external links available for Tle4.

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*Tle4^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Tle4^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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