Prpf39 | pre-mRNA processing factor 39
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Vision/eye Hematopoietic system Mortality/aging
17 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Prpf39em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Prpf39em1(IMPC)Tcp | heterozygote | Early adult | 6.76x10-8 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Prpf39em1(IMPC)Tcp | heterozygote | Early adult | 9.7x10-18 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Prpf39em1(IMPC)Tcp | heterozygote | Early adult | 9.5x10-15 | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Prpf39em1(IMPC)Tcp | homozygote | E15.5 | N/A * | ||
| decreased hematocrit | 1 supporting dataset | Prpf39em1(IMPC)Tcp | heterozygote | Early adult | 3.06x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Prpf39em1(IMPC)Tcp | heterozygote | Early adult | 2.77x10-5 | ||
| cataract | 1 supporting dataset | Prpf39em1(IMPC)Tcp | heterozygote | Early adult | 3.14x10-6 | ||
| abnormal eye morphology | 1 supporting dataset | Prpf39em1(IMPC)Tcp | heterozygote | Early adult | N/A * |
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External links
No external links available for Prpf39.
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| Prpf39em1(IMPC)Tcp | Deletion | | mouse |
| Prpf39tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Prpf39tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |