Xrcc5 | X-ray repair complementing defective repair in Chinese hamster cells 5

GeneMGI:104517Synonyms: Ku86, Ku80

Physiological systems

20 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Cardiovascular system Craniofacial Renal/urinary system Homeostasis/metabolism Limbs/digits/tail Vision/eye Liver/biliary system Behavior/neurological Skeleton

6 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:42Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased lean body mass	1 supporting dataset	Xrcc5^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.28x10^-5
abnormal thymus morphology	2 supporting datasets	Xrcc5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Xrcc5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal vertebrae morphology	1 supporting dataset	Xrcc5^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.4x10^-11
thin ventricular wall	1 supporting dataset	Xrcc5^{em1(IMPC)Ccpcz}	homozygote	Early adult	9.18x10^-6
increased liver weight	1 supporting dataset	Xrcc5^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.57x10^-5
abnormal testis morphology	1 supporting dataset	Xrcc5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased locomotor activity	1 supporting dataset	Xrcc5^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.67x10^-5
aorta stenosis	1 supporting dataset	Xrcc5^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.39x10^-21
short tibia	2 supporting datasets	Xrcc5^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.41x10^-21

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Xrcc5.

Associated images

Loading...

Histopathology

There is no histopathology data found for Xrcc5.

IMPC related publications

Loading...

External links

No external links available for Xrcc5.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Xrcc5^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse

My Genes