Ercc5 | excision repair cross-complementing rodent repair deficiency, complementation group 5
Physiological systems
21 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Mortality/aging
18 No significant impact
3 Not tested
Gene metrics:7Significant phenotypes
5Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Ercc5tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 2.74x10-36 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Ercc5tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 1.41x10-38 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ercc5tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased fasting circulating glucose level | 1 supporting dataset | Ercc5tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 8.09x10-5 | ||
| decreased hematocrit | 1 supporting dataset | Ercc5tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 1.87x10-24 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Ercc5tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 7.45x10-52 | ||
| thrombocytosis | 1 supporting dataset | Ercc5tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 2.03x10-66 |
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External links
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| Ercc5tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ercc5tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ercc5tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |