Cxcl12 | C-X-C motif chemokine ligand 12

GeneMGI:103556Synonyms: TPAR1, PBSF/SDF-1, +8 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Reproductive system Hematopoietic system Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

1Associated diseases

Expression examined in:73Adult tissues

43Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	2 supporting datasets	Cxcl12^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
hydrometra	1 supporting dataset	Cxcl12^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
thrombocytopenia	1 supporting dataset	Cxcl12^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.24x10^-5
abnormal uterus morphology	1 supporting dataset	Cxcl12^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
enlarged uterus	1 supporting dataset	Cxcl12^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cxcl12.

Associated images

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Histopathology

There is no histopathology data found for Cxcl12.

IMPC related publications

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External links

No external links available for Cxcl12.

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*Cxcl12^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Cxcl12^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Cxcl12^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cxcl12^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Cxcl12^{tm42159(L1L2_st1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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