Rbl1 | RB transcriptional corepressor like 1

GeneMGI:103300Synonyms: retinoblastoma-like 1 (p107), p107

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Cardiovascular system Mortality/aging Renal/urinary system

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Rbl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Rbl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
improved glucose tolerance	1 supporting dataset	Rbl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.99x10^-5
shortened QRS complex duration	1 supporting dataset	Rbl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.31x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rbl1.

Associated images

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Histopathology

There is no histopathology data found for Rbl1.

IMPC related publications

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External links

No external links available for Rbl1.

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*Rbl1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rbl1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Rbl1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rbl1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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