Tfeb | transcription factor EB

GeneMGI:103270Synonyms: TFEB, bHLHe35, +1 more

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

1Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	2 supporting datasets	Tfeb^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased lean body mass	1 supporting dataset	Tfeb^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.62x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Tfeb^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Tfeb^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Tfeb^{tm1b(EUCOMM)Wtsi}	heterozygote	E18.5	N/A ^*
increased total body fat amount	1 supporting dataset	Tfeb^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.04x10^-5
decreased hemoglobin content	1 supporting dataset	Tfeb^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.78x10^-5
increased lean body mass	2 supporting datasets	Tfeb^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.22x10^-5
trunk curl	1 supporting dataset	Tfeb^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.33x10^-5
decreased circulating alkaline phosphatase level	1 supporting dataset	Tfeb^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.87x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tfeb.

Associated images

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Histopathology

There is no histopathology data found for Tfeb.

IMPC related publications

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External links

No external links available for Tfeb.

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*Tfeb^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Tfeb^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tfeb^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tfeb^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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