Arhgef2 | Rho/Rac guanine nucleotide exchange factor 2

GeneMGI:103264Synonyms: Lbcl1, GEF-H1, +4 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Nervous system Vision/eye Liver/biliary system Hematopoietic system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal liver morphology	1 supporting dataset	Arhgef2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Arhgef2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small liver	1 supporting dataset	Arhgef2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
thrombocytopenia	1 supporting dataset	Arhgef2^em1(IMPC)Mbp	homozygote	Early adult	9.14x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Arhgef2^em1(IMPC)Mbp	homozygote	Early adult	2.13x10^-6
decreased brain size	1 supporting dataset	Arhgef2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Arhgef2^em1(IMPC)Mbp	homozygote	Early adult	6.02x10^-5
increased circulating total protein level	1 supporting dataset	Arhgef2^em1(IMPC)Mbp	homozygote	Early adult	3.5x10^-5
increased circulating serum albumin level	1 supporting dataset	Arhgef2^em1(IMPC)Mbp	homozygote	Early adult	4.22x10^-5
small spleen	1 supporting dataset	Arhgef2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arhgef2.

Associated images

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Histopathology

There is no histopathology data found for Arhgef2.

IMPC related publications

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External links

No external links available for Arhgef2.

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*Arhgef2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Arhgef2^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Arhgef2^{tm277613(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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