Mcm4 | minichromosome maintenance complex component 4

GeneMGI:103199Synonyms: 19G, mCdc21, +2 more

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Behavior/neurological Mortality/aging

18 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

2Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased grip strength	2 supporting datasets	Mcm4^{tm1b(KOMP)Mbp}	heterozygote	Early adult	1.83x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Mcm4^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Mcm4^{tm1b(KOMP)Mbp}	homozygote	E9.5	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Mcm4^{tm1b(KOMP)Mbp}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mcm4.

Associated images

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Histopathology

There is no histopathology data found for Mcm4.

IMPC related publications

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External links

No external links available for Mcm4.

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*Mcm4^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mcm4^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mcm4^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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