Uchl1 | ubiquitin carboxy-terminal hydrolase L1

GeneMGI:103149Synonyms: PGP9.5, PGP 9.5

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Skeleton

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

5Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:

Life Stage:



increased blood urea nitrogen level	1 supporting dataset	Uchl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	5.26x10^-5
increased startle reflex	1 supporting dataset	Uchl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.24x10^-5
hyperactivity	1 supporting dataset	Uchl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	2.62x10^-5
hyperactivity	1 supporting dataset	Uchl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8x10^-5
abnormal spine curvature	1 supporting dataset	Uchl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.76x10^-8
increased mean platelet volume	1 supporting dataset	Uchl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	9.12x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Uchl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.4x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Uchl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	2.69x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Uchl1.

Associated images

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Histopathology

There is no histopathology data found for Uchl1.

IMPC related publications

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External links

No external links available for Uchl1.

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*Uchl1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Uchl1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Uchl1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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