F10 | coagulation factor X

GeneMGI:103107Synonyms: AI194738, fX, +1 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Behavior/neurological Mortality/aging Renal/urinary system

15 No significant impact

4 Not tested

Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetF10tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
decreased circulating creatinine level1 supporting datasetF10tm1b(EUCOMM)HmguheterozygoteEarly adult6.56x10-5 
increased kidney weight1 supporting datasetF10tm1b(EUCOMM)HmguheterozygoteEarly adult7.47x10-5 
increased grip strength1 supporting datasetF10tm1b(EUCOMM)HmguheterozygoteEarly adult4.8x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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F10tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
F10tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
F10tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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