Stat1 | signal transducer and activator of transcription 1

GeneMGI:103063Synonyms: 2010005J02Rik

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Skeleton

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased neutrophil cell number	2 supporting datasets	Stat1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.01x10^-12
increased leukocyte cell number	1 supporting dataset	Stat1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	5.16x10^-10
decreased bone mineral content	1 supporting dataset	Stat1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	4.71x10^-5
increased eosinophil cell number	1 supporting dataset	Stat1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.78x10^-9
decreased lymphocyte cell number	1 supporting dataset	Stat1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.37x10^-10
decreased circulating alkaline phosphatase level	1 supporting dataset	Stat1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	5.25x10^-6
increased lymphocyte cell number	1 supporting dataset	Stat1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.56x10^-10
increased basophil cell number	1 supporting dataset	Stat1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	2.83x10^-6
decreased mean corpuscular volume	1 supporting dataset	Stat1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	8.67x10^-19
enlarged lymph nodes	2 supporting datasets	Stat1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Stat1.

Associated images

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Histopathology

There is no histopathology data found for Stat1.

IMPC related publications

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External links

No external links available for Stat1.

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*Stat1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Stat1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Stat1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Stat1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Stat1^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Stat1^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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