Cacna1c | calcium channel, voltage-dependent, L type, alpha 1C subunit

GeneMGI:103013Synonyms: D930026N18Rik, Cav1.2, +3 more

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Embryo Limbs/digits/tail Liver/biliary system Behavior/neurological Skeleton Mortality/aging Renal/urinary system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

10Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal placenta morphology	1 supporting dataset	Cacna1c^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
decreased locomotor activity	1 supporting dataset	Cacna1c^em1(IMPC)Mbp	heterozygote	Early adult	7.48x10^-5
abnormal caudal vertebrae morphology	1 supporting dataset	Cacna1c^em1(IMPC)Mbp	heterozygote	Early adult	1.19x10^-6
small kidney	1 supporting dataset	Cacna1c^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Cacna1c^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Cacna1c^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
increased freezing behavior	1 supporting dataset	Cacna1c^em1(IMPC)Mbp	heterozygote	Early adult	2.25x10^-6
abnormal kidney morphology	1 supporting dataset	Cacna1c^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	2 supporting datasets	Cacna1c^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small liver	1 supporting dataset	Cacna1c^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cacna1c.

Associated images

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Histopathology

There is no histopathology data found for Cacna1c.

IMPC related publications

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External links

No external links available for Cacna1c.

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*Cacna1c^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Cacna1c^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cacna1c^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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