Pdx1 | pancreatic and duodenal homeobox 1

GeneMGI:102851Synonyms: Ipf1, IDX-1, +4 more

Physiological systems

21 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging

19 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

6Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	3 supporting datasets	Pdx1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
impaired glucose tolerance	1 supporting dataset	Pdx1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.67x10^-14

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pdx1.

Associated images

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Histopathology

There is no histopathology data found for Pdx1.

IMPC related publications

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External links

No external links available for Pdx1.

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*Pdx1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pdx1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pdx1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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