Cav1 | caveolin 1, caveolae protein

GeneMGI:102709Synonyms: Cav-1, caveolin-1

Physiological systems

16 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Muscle Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased heart rate	1 supporting dataset	Cav1^em2(IMPC)Ics	homozygote	Early adult	5.53x10^-5
decreased grip strength	2 supporting datasets	Cav1^em2(IMPC)Ics	homozygote	Early adult	1.4x10^-5
increased circulating cholesterol level	1 supporting dataset	Cav1^em2(IMPC)Ics	homozygote	Early adult	1.13x10^-17
increased mean corpuscular hemoglobin	1 supporting dataset	Cav1^em2(IMPC)Ics	homozygote	Early adult	8.31x10^-5
decreased cardiac muscle contractility	1 supporting dataset	Cav1^em2(IMPC)Ics	homozygote	Early adult	3.4x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Cav1^em2(IMPC)Ics	homozygote	Early adult	1.7x10^-12
increased hemoglobin content	1 supporting dataset	Cav1^em2(IMPC)Ics	homozygote	Early adult	2.79x10^-6
increased mean corpuscular volume	1 supporting dataset	Cav1^em2(IMPC)Ics	homozygote	Early adult	8.71x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cav1.

Associated images

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Histopathology

There is no histopathology data found for Cav1.

IMPC related publications

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External links

No external links available for Cav1.

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*Cav1^em2(IMPC)Ics*	Deletion	‌	mouse
*Cav1^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cav1^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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