Ppp5c | protein phosphatase 5, catalytic subunit

GeneMGI:102666Synonyms: ANP receptor, PP5

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Growth/size/body region Skeleton

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal rib morphology	2 supporting datasets	Ppp5c^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.31x10^-8
vertebral fusion	1 supporting dataset	Ppp5c^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.98x10^-6
increased thoracic vertebrae number	1 supporting dataset	Ppp5c^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.85x10^-6
abnormal coat/hair pigmentation	1 supporting dataset	Ppp5c^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.28x10^-6
increased lumbar vertebrae number	2 supporting datasets	Ppp5c^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.18x10^-6
decreased circulating triglyceride level	1 supporting dataset	Ppp5c^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.15x10^-11
decreased body length	1 supporting dataset	Ppp5c^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.39x10^-5
increased rib number	2 supporting datasets	Ppp5c^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.09x10^-7
decreased circulating glucose level	1 supporting dataset	Ppp5c^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.76x10^-8
increased lean body mass	1 supporting dataset	Ppp5c^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.84x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ppp5c.

Associated images

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Histopathology

There is no histopathology data found for Ppp5c.

IMPC related publications

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External links

No external links available for Ppp5c.

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*Ppp5c^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ppp5c^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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