Ptpn14 | protein tyrosine phosphatase, non-receptor type 14

GeneMGI:102467Synonyms: OTTMUSG00000022087, PTP36, +1 more

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Reproductive system Growth/size/body region Cardiovascular system Mortality/aging Renal/urinary system

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

29Embryo tissues

Phenotypes

Phy. System:

Life Stage:



enlarged uterus	1 supporting dataset	Ptpn14^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased lean body mass	2 supporting datasets	Ptpn14^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.09x10^-6
hydrometra	1 supporting dataset	Ptpn14^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Ptpn14^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Ptpn14^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Ptpn14^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
single kidney	1 supporting dataset	Ptpn14^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Ptpn14^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Ptpn14^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
enlarged heart	1 supporting dataset	Ptpn14^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ptpn14.

Associated images

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Histopathology

There is no histopathology data found for Ptpn14.

IMPC related publications

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External links

No external links available for Ptpn14.

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*Ptpn14^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Ptpn14^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Ptpn14^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ptpn14^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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