Mlh1 | mutL homolog 1
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system
13 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
5Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| cataract | 1 supporting dataset | Mlh1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.76x10-5 | ||
| small testis | 1 supporting dataset | Mlh1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased spleen weight | 1 supporting dataset | Mlh1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.03x10-39 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Mlh1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.21x10-7 | ||
| male infertility | 1 supporting dataset | Mlh1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Mlh1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.35x10-11 |
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External links
No external links available for Mlh1.
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| Mlh1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mlh1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mlh1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |