Pla2g5 | phospholipase A2, group V

GeneMGI:101899Synonyms: sPLA2

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased startle reflex	1 supporting dataset	Pla2g5^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.36x10^-5
abnormal lymph node morphology	1 supporting dataset	Pla2g5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
cardiovascular system phenotype	1 supporting dataset	Pla2g5^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.43x10^-7
increased eosinophil cell number	2 supporting datasets	Pla2g5^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.74x10^-13
increased circulating alkaline phosphatase level	1 supporting dataset	Pla2g5^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.42x10^-5
small testis	1 supporting dataset	Pla2g5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Pla2g5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Pla2g5^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
prolonged RR interval	1 supporting dataset	Pla2g5^{em1(IMPC)Ccpcz}	homozygote	Early adult	8.92x10^-5
abnormal sinus arrhythmia	1 supporting dataset	Pla2g5^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.11x10^-19

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pla2g5.

Associated images

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Histopathology

There is no histopathology data found for Pla2g5.

IMPC related publications

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External links

No external links available for Pla2g5.

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*Pla2g5^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Pla2g5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Pla2g5^{tm39187(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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