Thpo | thrombopoietin

GeneMGI:101875Synonyms: TPO-2, TPO-3, +5 more

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Respiratory system Hematopoietic system Skeleton Craniofacial

15 No significant impact

3 Not tested

Gene metrics:7Significant phenotypes
7Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

decreased pulmonary ventilation2 supporting datasetsThpotm1.1(KOMP)VlcghomozygoteEarly adult1.41x10-12 
decreased bronchoconstrictive response1 supporting datasetThpotm1.1(KOMP)VlcghomozygoteEarly adult2.54x10-7 
thrombocytopenia1 supporting datasetThpotm1.1(KOMP)VlcghomozygoteEarly adult3.63x10-6 
increased mean platelet volume1 supporting datasetThpotm1.1(KOMP)VlcghomozygoteEarly adult3.21x10-6 
abnormal cranium morphology1 supporting datasetThpotm1.1(KOMP)VlcghomozygoteEarly adult1.74x10-5 
cornea opacity1 supporting datasetThpotm1.1(KOMP)VlcghomozygoteEarly adult8.45x10-5 
increased pulmonary respiratory rate1 supporting datasetThpotm1.1(KOMP)VlcghomozygoteEarly adult9.79x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* This parameter was manually assessed for significance.
Download data as:  

lacZ Expression

Associated images

Loading...

Histopathology

IMPC related publications

Loading...

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

Thpotm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Thpotm1(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Thpotm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Thpotm2(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter