Mtf1 | metal response element binding transcription factor 1

GeneMGI:101786Synonyms: metalloregulatory transcription factor, metal response element-binding transcription factor 1, +2 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Craniofacial Mortality/aging

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



microphthalmia	1 supporting dataset	Mtf1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Mtf1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.28x10^-5
abnormal forebrain morphology	1 supporting dataset	Mtf1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal embryo size	1 supporting dataset	Mtf1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Mtf1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal retina morphology	1 supporting dataset	Mtf1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.79x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Mtf1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
anophthalmia	1 supporting dataset	Mtf1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
decreased circulating glucose level	1 supporting dataset	Mtf1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.85x10^-5
abnormal craniofacial morphology	1 supporting dataset	Mtf1^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mtf1.

Associated images

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Histopathology

There is no histopathology data found for Mtf1.

IMPC related publications

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External links

No external links available for Mtf1.

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*Mtf1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mtf1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mtf1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Mtf1^{tm36746(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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