Ryk | receptor-like tyrosine kinase

GeneMGI:101766Synonyms: ERK-3, Vik

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Embryo Growth/size/body region Digestive/alimentary Vision/eye Hematopoietic system Craniofacial Mortality/aging Cardiovascular system Renal/urinary system

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal placenta morphology	1 supporting dataset	Ryk^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Ryk^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
edema	1 supporting dataset	Ryk^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal skin morphology	1 supporting dataset	Ryk^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Ryk^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Ryk^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Ryk^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
cleft palate	1 supporting dataset	Ryk^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
eye hemorrhage	1 supporting dataset	Ryk^em1(IMPC)Mbp	heterozygote	Early adult	2.06x10^-7
increased monocyte cell number	1 supporting dataset	Ryk^em1(IMPC)Mbp	heterozygote	Early adult	6.24x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ryk.

Associated images

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Histopathology

There is no histopathology data found for Ryk.

IMPC related publications

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External links

No external links available for Ryk.

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*Ryk^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ryk^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Ryk^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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