Acan | aggrecan

GeneMGI:99602Synonyms: b2b183Clo, Agc1, +1 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Immune system Hematopoietic system Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

7Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Acan^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased basophil cell number	1 supporting dataset	Acan^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.4x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Acan.

Associated images

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Histopathology

There is no histopathology data found for Acan.

IMPC related publications

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External links

No external links available for Acan.

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*Acan^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Acan^{tm1.1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	ES Cell mouse
*Acan^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Acan^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Acan^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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